副校長

1.

Hsieh YC, Liao JM, Chuang KH, Ho KW, Hong ST, Liu HJ, Huang BC, Chen IJ, Liu YL, Wang JY, Tsai HL, Su YC, Wang YT, Cheng TL*. A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies. J Nanobiotechnology. 2022 Jan 31;20(1):58. (2022 SCI IF=10.2 (SCI, 12/156=7.69%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

2.

Cheng KW, Tseng CH, Chen IJ, Huang BC, Liu HJ, Ho KW, Lin WW, Chuang CH, Huang MY, Leu YL, Roffler SR, Wang JY, Chen YL, Cheng TL*. Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis. Pharmacol Res. 2022 Mar;177:106115. (2022 SCI IF=9.3 (SCI, 15/277=5.41%) in PHARMACOLOGY & PHARMACY)

3.

Huang BC, Lu YC, Liao JM, Liu HJ, Hong ST, Hsieh YC, Chuang CH, Chen HJ, Liao TY, Ho KW, Wang YT, Cheng TL*. Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies. Chem Sci. 2021 Jun 14;12(28):9759-9769. (2022 SCI IF=8.4 (SCI, 32/178=17.97%) in CHEMISTRY, MULTIDISCIPLINARY)

4.

Hong ST, Su YC, Wang YJ, Cheng TL*, Wang YT*.Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study. Biomolecules. 2021 Feb 23;11(2):334. (2022 SCI IF= 5.5 (SCI, 70/285=24.56%) in BIOCHEMISTRY & MOLECULAR BIOLOGY)

5.

Ho KW, Chen IU, Cheng YA, Liao TY, Liu ES, Chen HJ, Lu YC, Su YC, Roffler SR, Huang BC, Liu HJ, Huang MY, Chen CY, Cheng TL*. Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity. J Nanobiotechnology. 2021 Jan 9;19(1):16. (2022 SCI IF=10.2 (SCI, 12/156=7.69%) in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

6.

Wang YT, Cheng TL*. Computational modeling of cyclic peptide inhibitor-MDM2/MDMX binding through global docking and Gaussian accelerated molecular dynamics simulations. J Biomol Struct Dyn. 2020 Jun 8:1-10. (2022 SCI IF= 4.4 (SCI, 15/70=21.42%) in BIOPHYSICS)

7.

Lin WW, Lu YC, Chuang CH, Cheng TL*. Ab locks for improving the selectivity and safety of antibody drugs. J Biomed Sci. 2020 Jun 25;27(1):76. (2022 SCI IF= 11.0 (SCI, 13/136=9.55%) in MEDICINE, RESEARCH & EXPERIMENTAL)

8.

Chen IJ, Cheng YA, Ho KW, Lin WW, Cheng KW, Lu YC, Hsieh YC, Huang CC, Chuang CH, Chen FM, Su YC, Roffler SR, Cheng TL*; Bispecific Antibody (HER2 × mPEG) Enhances Anti-Cancer Effects by Precise Targeting and Accumulation of mPEGylated Liposomes. Acta Biomater. 2020 Jul 15;111:386-397. (2022 SCI IF= 9.7 (SCI, 9/96=9.37%) in ENGINEERING, BIOMEDICAL)

9.

Cheng YA, Chen IJ, Su YC, Cheng KW, Lu YC, Lin WW, Hsieh YC, Kao CH, Chen FM, Roffler SR*, Cheng TL*; Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer. Biomater Sci. 2019 Aug 1;7(8):3404-3417. (2022 SCI IF=6.6 (SCI, 12/45=26.66%) in MATERIALS SCIENCE, BIOMATERIALS)

10.

Cheng KW, Tseng CH, Tzeng CC, Leu YL, Cheng TC, Wang JY, Chang JM, Lu YC, Cheng CM, Chen IJ, Cheng YA, Chen YL*, Cheng TL*. Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo. Pharmacol Res. 2019 Jan;139:41-49. (2022 SCI IF=9.3 (SCI, 15/277=5.41%) in PHARMACOLOGY & PHARMACY) 

11.

Hsieh YC, Wang HE, Lin WW, Roffler SR, Cheng TC, Su YC, Li JJ, Chen CC, Huang CH, Chen BM, Wang JY, Cheng TL*, Chen FM*. Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes. Theranostics. 2018 May 9;8(11):3164-3175. (2022 SCI IF= 12.4 (SCI, 8/136=5.88%) in MEDICINE, RESEARCH & EXPERIMENTAL)

12.

Su YC, Burnouf PA, Chuang KH, Chen BM, Cheng TL*, Roffler SR*. Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy. Nat Commun. 2017 Jun 8;8:15507. (2022 SCI IF= 16.6 (SCI, 6/73=8.21%) in MULTIDISCIPLINARY SCIENCES)

13.

Lin WW, Cheng YA, Kao CH, Roffler SR, Lee YC, Chen BM, Hsieh YC, Chen IJ, Huang BC, Wang YT, Tung YC, Huang MY, Chen FM, Cheng TL*. Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules. Anal Chem. 2017 Jun 6;89(11):6082-6090. (2022 SCI IF= 7.4 (SCI, 7/86=8.13%) in CHEMISTRY, ANALYTICAL)

14.

Cheng KW, Tseng CH, Yang CN, Tzeng CC, Cheng TC, Leu YL, Chuang YC, Wang JY, Lu YC, Chen YL*, Cheng TL*. Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity. J Med Chem. 2017 Nov 22;60(22):9222-9238. (2022 SCI IF= 7.3 (SCI, 4/60=6.66%) in CHEMISTRY, ANALYTICAL)